11/6/2022 0 Comments 1st mtp![]() ![]() Studies which assessed the 1 st MTP amongst other joints, but did not report outcome measures specifically relating to the 1 st MTP, were also excluded.Ī meta-analysis was conducted to obtain an estimate of the prevalence of acute arthritis at the 1 st MTP in people with gout at any point during the course of their disease. Studies investigating outcomes as a measure of pharmacological, non-pharmacological and surgical intervention efficacy were excluded. Included studies presented original findings relating to the following outcome measures: incidence or prevalence of acute inflammatory arthritis at the 1 st MTP clinical features of acute gouty arthritis, intercritical gout and chronic gouty arthropathy (including tophaceous gout) at the 1 st MTP structural and functional characteristics of the 1 st MTP microscopy of the 1 st MTP and imaging features of the 1 st MTP including MSU crystals, bone disease and synovial disease. ![]() The inclusion criteria included studies published in English, adults over 18 years old and which involved participants who had a diagnosis of gout. #1st mtp seriesCase reports, case series with <5 cases and review articles were excluded. Peer-reviewed conference proceedings and abstracts were also considered for inclusion. Studies considered for this review were published in peer-reviewed journals and limited to randomised controlled trials, cohort studies, case-control studies and cross-sectional studies. The review was conducted with reference to the Preferred Reporting Items for Systematic review and Meta-Analysis protocols (PRISMA) statement. This systematic review aimed to qualitatively synthesise studies which have investigated characteristics of the 1 st MTP in gout and to undertake a meta-analysis to provide a pooled estimate for the average prevalence of acute 1 st MTP arthritis in gout across studies.Īll potentially eligible articles were screened by a single author (SS) at title, abstract, and full-text stages. Despite the significant role of the 1 st MTP during normal gait, particularly the forward transfer of body weight during propulsion, it is also unclear to what extent the structure and function of the joint is compromised in people with gout. ![]() Furthermore, the burden of 1 st MTP involvement on patient-reported outcomes in gout is unclear. ĭespite the well-recognised susceptibility of the 1 st MTP to acute arthritis in gout, evident by its inclusion in several gout diagnostic and classification criteria, a formal synthesis of the prevalence of acute 1 st MTP arthritis in this condition has yet to be undertaken. Gout has a major impact on health-related quality of life and its tendency to affect the foot is reflected in the high levels of foot-related disability and impairment. In recent decades, lifestyle and dietary factors associated with hyperuricaemia have become increasingly widespread, as has the global burden of gout. Acute episodes of gouty arthritis at the 1 st MTP are often referred to as podagra. ![]() Gout is well recognised by its predilection to affect the first metatarsophalangeal joint (1 st MTP). If left untreated, gout can progress to a chronic arthritis with tophus formation and joint damage. Clinically, gout is characterised by painful flares of acute monoarthritis interspersed with asymptomatic periods. Gout, one of the most common forms of inflammatory arthritis in middle-aged men, is caused by monosodium urate (MSU) crystal deposition in joints and soft tissue. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |